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KMID : 0603820070130020153
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 2 p.153 ~ p.155
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Endoplnsmic Reticulum Stress Up-regulates Ferritin Heavy Chain 1 Expression
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Jin Cho-Yi
Kwon Ki-Sang
Goo Tae-Won
Kwon O-Yu
Yun Eun-Young
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Abstract
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Ferritin heavy chain 1 (FTH1) is an ubiquitous and highly conserved protein which plays a major role in iron homeostasis. The expression of FTH1 was specifically enhanced under various condition of endoplasmic reticulum (ER) stresses drugs such as Brefeldin A (BFA), DTT (Dithiothreitol), calcium ionophore A23187 and tunicamycin. We firstly report here that ER-stress induces up-regulated expression of FTH1 in FRTL-5 culture thyrocytes.
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KEYWORD
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Endoplasmic reticulum (ER), Ferritin heavy chain 1 (FTH1), ER-stress inducible drugs
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